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RAA pathway

When blood osmolarity is too high, that means the blood has too many solutes and not enough water.

You would want to reabsorb water from the collecting duct into the blood, to dilute your blood and bring the blood osmolarity back down to normal.

So you would want to secrete ADH.

But how does your body know your blood osmolarity is too high?

The cells in the hypothalamus know, because a change in blood osmolarity causes their size to change.

shrink

swell